Title: Schizophrenia Susceptibility and Nmda-receptor Mediated Signalling: an Association Study Involving 47 Tagsnps of Dao, Daoa, Ppp3cc, and Dtnbp1 Genes Authors
نویسندگان
چکیده
Emilio Sacchetti ([email protected]) Catia Scassellati ([email protected]) Alessandra Minelli ([email protected]) Paolo Valsecchi ([email protected]) Cristian Bonvicini ([email protected]) Patrizio Pasqualetti ([email protected]) Alessandro Galluzzo ([email protected]) Rosaria Pioli ([email protected]) Massimo Gennarelli ([email protected])
منابع مشابه
Author's response to reviews Title: Schizophrenia susceptibility and NMDA-receptor mediated signalling: an association study involving 47 tagSNPs of DAO, DAOA, PPP3CC, and DTNBP1 genes Authors:
Emilio Sacchetti ([email protected]) Catia Scassellati ([email protected]) Alessandra Minelli ([email protected]) Paolo Valsecchi ([email protected]) Cristian Bonvicini ([email protected]) Patrizio Pasqualetti ([email protected]) Alessandro Galluzzo ([email protected]) Rosaria Pioli ([email protected]) Massimo G...
متن کاملThe genetics of schizophrenia and bipolar disorder: dissecting psychosis.
Much work has been done to identify susceptibility genes in schizophrenia and bipolar disorder. Several well established linkages have emerged in schizophrenia. Strongly supported regions are 6p24-22, 1q21-22, and 13q32-34, while other promising regions include 8p21-22, 6q16-25, 22q11-12, 5q21-q33, 10p15-p11, and 1q42. Genomic regions of interest in bipolar disorder include 6q16-q22, 12q23-q24,...
متن کاملSchizophrenia: genes at last?
Genetic epidemiological studies suggest that individual variation in susceptibility to schizophrenia is largely genetic, reflecting alleles of moderate to small effect in multiple genes. Molecular genetic studies have identified several potential regions of linkage and two associated chromosomal abnormalities, and evidence is accumulating in favour of several positional candidate genes. Current...
متن کاملNo significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics.
OBJECTIVE The authors carried out a genetic association study of 14 schizophrenia candidate genes (RGS4, DISC1, DTNBP1, STX7, TAAR6, PPP3CC, NRG1, DRD2, HTR2A, DAOA, AKT1, CHRNA7, COMT, and ARVCF). This study tested the hypothesis of association of schizophrenia with common single nucleotide polymorphisms (SNPs) in these genes using the largest sample to date that has been collected with unifor...
متن کاملControversial Effects of D-Amino Acid Oxidase Activator (DAOA)/G72 on D-Amino Acid Oxidase (DAO) Activity in Human Neuronal, Astrocyte and Kidney Cell Lines: The N-methyl D-aspartate (NMDA) Receptor Hypofunction Point of View
Dysfunction of D-amino acid oxidase (DAO) and DAO activator (DAOA)/G72 genes have been linked to neuropsychiatric disorders. The glutamate hypothesis of schizophrenia has proposed that increased DAO activity leads to decreased D-serine, which subsequently may lead to N-methyl-D-aspartate (NMDA) receptor hypofunction. It has been shown that DAOA binds to DAO and increases its activity. However, ...
متن کامل